EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF

Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. L'invention concerne, en partie, des composés (I) qui sont des dérivés d'exatecan avec de nouveaux li...

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Hauptverfasser:	STROP, PETER, WONG, JANICA CHEUK-YING, PONS, JAUME, VRLJIC, MARIJA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein, in part, are compounds (I) which are exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies. L'invention concerne, en partie, des composés (I) qui sont des dérivés d'exatecan avec de nouveaux lieurs chimiques qui comprennent des fractions clivables de la cathepsine B, et conjugués à des anticorps de ciblage.