ENGINEERED GUANYLATE KINASE VARIANT ENZYMES

The present invention provides engineered guanylate kinase (GK) enzymes, polypeptides having GK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GK enzymes are also provided. The present i...

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Bibliographische Detailangaben
Hauptverfasser:	PETKOVA, AKSINIYA LYUBENOVA, DUAN, DA, SOWELL-KANTZ, AURIC ANTHONY, ALVIZO, OSCAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides engineered guanylate kinase (GK) enzymes, polypeptides having GK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GK enzymes are also provided. The present invention further provides compositions comprising the GK enzymes and methods of using the engineered GK enzymes. The present invention finds particular use in the production of pharmaceutical compounds. La présente invention concerne des enzymes guanylate kinase (GK) modifiées, des polypeptides ayant une activité GK, et des polynucléotides codant pour ces enzymes, ainsi que des vecteurs et des cellules hôtes comprenant ces polynucléotides et polypeptides. L'invention concerne également des méthodes de production d'enzymes GK. La présente invention concerne en outre des compositions comprenant les enzymes GK et des méthodes d'utilisation des enzymes GK modifiées. La présente invention trouve une utilisation particulière dans la production de composés pharmaceutiques.