ANTI-HER2 ANTIBODY-DRUG CONJUGATES AND USES THEREOF

Disclosed herein are antibody-drug conjugates (ADCs) whose antibodies include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The ADCs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dic...

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Bibliographische Detailangaben
Hauptverfasser:	LIANG, XUEJUN, XIA, GANG, XIONG, GAOZHUN, TIAN, FENG, YAN, JINCHUN, JI, YANPING, YAO, SULAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed herein are antibody-drug conjugates (ADCs) whose antibodies include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The ADCs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid ADCs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such ADCs. Typically, the modified ADCs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid ADCs and modified non-natural amino acid ADCs, including therapeutic, diagnostic, and other biotechnology use. L'invention concerne des conjugués anticorps-médicament (CAM) dont les anticorps comprennent au moins un acide aminé non naturel, et des procédés de fabrication de tels polypeptides et acides aminés non naturels. Les CAM peuvent inclure une large gamme de fonctionnalités possibles, mais comportent généralement au moins un groupe oxime, carbonyle, dicarbonyle et/ou hydroxylamine. L'invention concerne également des CAM d'acides aminés non naturels qui sont encore modifiés de manière post-traductionnelle, des procédés pour effectuer de telles modifications, et des procédés pour purifier de tels CAM. Typiquement, les CAM modifiés comprennent au moins un groupe oxime, carbonyle, dicarbonyle et/ou hydroxylamine. L'invention concerne en outre des méthodes d'utilisation de tels CAM d'acides aminés non naturels et de CAM d'acides aminés non naturels modifiés, y compris l'utilisation thérapeutique, diagnostique et autre biotechnologie.