INHIBITORS OF THE MENIN-MLL INTERACTION

INHIBITORS OF THE MENIN-MLL INTERACTION

The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other d...

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Bibliographische Detailangaben
Hauptverfasser: CAMP, NICHOLAS PAUL, REDDY, VIRSINHA VENKAT, KULKARNI, SANTOSH S, MCGEEHAN, GERARD M, SAMANTA, SWAPAN KUMAR, CACATIAN, SALVACION, MILLER, WILLIAM H
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction. La présente invention concerne des composés de formule (0), ou un stéréoisomère de ceux-ci, ou un sel pharmaceutiquement acceptable de ceux-ci, inhibiteurs de l'interaction entre la ménine et MLL et des protéines de fusion MLL, des compositions pharmaceutiques les contenant, et leur utilisation dans le traitement du cancer et d'autres maladies médiées par l'interaction ménine-MLL.