COMPOSITIONS AND METHODS FOR MODULATING EPITHELIAL-MESENCHYMAL TRANSITION

The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, inhibitors and blockers, to modulate, suppress and stabilize epithelial-mesenchymal and/or endothelial-mesenchymal transition in diseases, disorders and conditions, including fib...

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Hauptverfasser:	MUGISHO, ODUNAYO OMOLOLA BOLUWARIN, GREEN, COLIN RICHARD, LEVY, BRIAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The inventions relate to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, inhibitors and blockers, to modulate, suppress and stabilize epithelial-mesenchymal and/or endothelial-mesenchymal transition in diseases, disorders and conditions, including fibrotic diseases, disorders and conditions and other conditions associated with fibrosis. L'invention concerne l'utilisation de composés anti-hémicanaux, comprenant des composés d'ouverture des hémicanaux anti-connexine 43, des inhibiteurs et des bloqueurs, pour moduler, supprimer et stabiliser une transition épithélio-mésenchymateuse et/ou endothéliale-mésenchymateuse dans des maladies, des troubles et des états, notamment des maladies, troubles et états fibrotiques et autres états associés à la fibrose.