SMALL MOLECULE INHIBITORS OF PBRM1-BD2

SMALL MOLECULE INHIBITORS OF PBRM1-BD2

The present disclosure provides novel inhibitors of PBRM1, specifically the 2nd bromodomain of PBRM1 (PBRM1-BD2), pharmaceutical compositions and methods of use thereof. La présente invention concerne de nouveaux inhibiteurs de PBRM1, plus spécifiquement le 2ème bromodomaine de PBRM1 (PBRM1-BD2), de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHISHODIA, SHIFALI, SMITH, BRIAN CHRISTOPHER, GOETZ, CHRISTOPHER J, OLP, MICHAEL D
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides novel inhibitors of PBRM1, specifically the 2nd bromodomain of PBRM1 (PBRM1-BD2), pharmaceutical compositions and methods of use thereof. La présente invention concerne de nouveaux inhibiteurs de PBRM1, plus spécifiquement le 2ème bromodomaine de PBRM1 (PBRM1-BD2), des compositions pharmaceutiques et leurs méthodes d'utilisation.