REGULATORY T CELL (TREG) EXTRACELLULAR VESICLE COMPOSITIONS AND METHODS

The present disclosure provides anti-inflammatory extracellular vesicles (EVs) derived from ex vivo-expanded human suppressive immune cells, e.g., regulatory T cells (Tregs). Such EVs are useful in the treatment of diseases such as amyotrophic lateral sclerosis (AES), Alzheimer's disease, and o...

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Bibliographische Detailangaben
Hauptverfasser:	THONHOFF, JASON ROBERT, THOME, AARON DREW, APPEL, STANLEY HERSH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides anti-inflammatory extracellular vesicles (EVs) derived from ex vivo-expanded human suppressive immune cells, e.g., regulatory T cells (Tregs). Such EVs are useful in the treatment of diseases such as amyotrophic lateral sclerosis (AES), Alzheimer's disease, and other neurological diseases, as well as inflammatory and autoimmune diseases or dysfunctions. La présente divulgation concerne des vésicules extracellulaires anti-inflammatoires (EV) dérivées de cellules immunitaires suppressives humaines étendues ex vivo, par exemple, des lymphocytes T régulateurs (treg). De telles EV sont utiles dans le traitement de maladies telles que la slérose latérale amyotrophique (AES), la maladie d'Alzheimer et d'autres maladies neurologiques, ainsi que des maladies ou des dysfonctionnements inflammatoires et auto-immuns.