4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL)METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL)PHENOXY)-1-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE

4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL)METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL)PHENOXY)-1-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE

The present invention relates to 4-(2-Fluoro-4-methoxy-5-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl) carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid derivatives and similar compounds of formula (I) as RXFP1 modulators for the treatment of heart failure, heart failur...

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Hauptverfasser: FUCHIGAMI, RYUICHI, FUJIO, MASAKAZU, ULANDER, LARS JOHAN ANDREAS, BOSTROM, STIG JONAS, GRADEN, HENRIK, BERGONZINI, GIULIA, SAKAMAKI, SHIGEKI, BERGSTROM, HANS FREDRIK, NIWA, YASUKI, GRANBERG, KENNETH LARS
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates to 4-(2-Fluoro-4-methoxy-5-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl) carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid derivatives and similar compounds of formula (I) as RXFP1 modulators for the treatment of heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. The present invention also relates to crystalline forms of such compounds. An exemplary compound is e.g. (A). La présente invention concerne des dérivés d'acide 4-(2-fluoro-4-méthoxy-5-3-(((l-méthylcyclobutyle)méthyle)carbamoyle)bicyclo [2.2.1] heptan-2-yl)carbamoyl)phénoxy)-l-méthylcyclohexane-l-carboxylique et des composés similaires représentés par la formule (I) utilisés comme modulateurs de RXFP1 pour le traitement de l'insuffisance cardiaque, l'insuffisance cardiaque à fraction d'éjection préservée, l'insuffisance cardiaque à fraction d'éjection moyennement réduite, l'insuffisance cardiaque à fraction d'éjection réduite, la néphropathie chronique et l'insuffisance rénale aiguë. La présente invention concerne également des formes cristallines de tels composés. Un composé donné à titre d'exemple est par exemple (A).