METHODS OF TREATING BREAST CANCER WITH TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS

The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, sol...

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Bibliographische Detailangaben
Hauptverfasser:	TAYLOR, IAN CHARLES ANTHONY, CHEN, XIN, GOUGH, SHERYL MAXINE, MOORE, MARCIA DOUGAN, WANG, JING, CREW, ANDREW P, FLANAGAN, JOHN, HASKELL, III, QIAN, YIMIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein. La présente demande concerne le traitement et/ou la prévention du cancer du sein, y compris le cancer du sein localement avancé ou métastatique, ER+, HER2-, chez un sujet ayant besoin d'un traitement, comprenant l'administration d'un composé de formule (I) ou d'un sel, d'un énantiomère, d'un stéréoisomère, d'un solvate, d'un polymorphe, d'un dérivé isotopique ou d'un promédicament pharmaceutiquement acceptable de celui-ci, R1, R2, R3, R4, m et n étant tels que définis dans la description.