MACROCYCLES CONTAINING A 1,3,4-OXADIAZOLE RING FOR USE AS MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulato...

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Hauptverfasser:	HADIDA RUAH, SARA SABINA, GROOTENHUIS, PETER DIEDERIK JAN, BOOKSER, BRETT C, GALLANT, MICHEL, BECHARA, WILLIAM SCHULZ, STURINO, CLAUDIO, REDDY, THUMKUNTA JAGADEESWAR, ZHOU, JINGLAN, PARASELLI, PRASUNA, RAMTOHUL, YEEMAN K, CLEVELAND, THOMAS, VALDEZ, LINO, LATERREUR, JULIE, CLEMENS, JEREMY J, COON, TIMOTHY, MILLER, MARK THOMAS, BAEK, MINSON
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators. La présente invention concerne des modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique (CFTR), des compositions pharmaceutiques contenant au moins un tel modulateur, des méthodes de traitement de la fibrose kystique à l'aide de tels modulateurs et des compositions pharmaceutiques, et des procédés de fabrication de tels modulateurs.