CRYSTALLINE FORMS OF 4-AMINO-N-[4-(METHOXYMETHYL)PHENYL]-7-(1-METHYLCYCLOPROPYL)-6-(3-MORPHOLINOPROP-1-YN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE, METHODS OF PREPARATION, AND USES THEREOF

CRYSTALLINE FORMS OF 4-AMINO-N-[4-(METHOXYMETHYL)PHENYL]-7-(1-METHYLCYCLOPROPYL)-6-(3-MORPHOLINOPROP-1-YN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE, METHODS OF PREPARATION, AND USES THEREOF

Provided herein are various crystalline forms of 4-amino-N-[4-(methoxymethyl)phenyl]-7-(1- methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5- carboxamide, methods of producing same, and methods of using same to for RET inhibition. L'invention concerne diverses form...

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Hauptverfasser: FUMAGALLI, TIZIANO, MODENA, ENRICO, GIAFFREDA, STEFANO LUCA, FRASCA, GIONATA, IANNI, CRISTINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are various crystalline forms of 4-amino-N-[4-(methoxymethyl)phenyl]-7-(1- methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5- carboxamide, methods of producing same, and methods of using same to for RET inhibition. L'invention concerne diverses formes cristallines de 4-amino-N-[4-(méthoxyméthyl)phényl]-7-(1-méthylcyclopropyle)-6-(3-morpholinoprop-1-yn-1-yl)-7 H-pyrrolo[2,3-d]pyrimidine-5-carboxamide, des procédés de production de celles-ci, et des procédés d'utilisation de celles-ci pour inhiber RET.