IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF

IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF

Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles. L'invention concerne des nanoparticules lipidiques et des lipides cationiques ionisables...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ALI, MIR, KUHLMAN, WILLIAM, BOESCH, AUSTIN WAYNE, DRUMMOND, DARYL CLARK, NIELSEN, ULRIK
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles. L'invention concerne des nanoparticules lipidiques et des lipides cationiques ionisables pour l'administration d'acides nucléiques à des cellules (par exemple, des cellules immunitaires), et des méthodes de fabrication et d'utilisation de tels lipides et nanoparticules lipidiques ciblées.