ANTI-CD48 ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND USES THEREOF

Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and...

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Hauptverfasser:	D'ALESSIO, JOSEPH ANTHONY, MUNDT, CORNELIA ANNE, WINKELBACH, KATHARINA, SCHWEIGHOFFER, TAMAS, NEWCOMBE, RICHARD VAUGHAN, KLINTER, CLAUDIA JUDITH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof that bind human CD48. Also disclosed are pharmaceutical compositions comprising the antibodies, antigen binding fragments thereof, and antibody drug conjugates thereof; and methods of making and using such pharmaceutical compositions for treating cancer in a patient in need of treatment. L'invention concerne des anticorps, des fragments de liaison à l'antigène de ceux-ci, et des conjugués anticorps-médicament de ceux-ci qui se lient à CD48 humain. L'invention concerne également des compositions pharmaceutiques comprenant les anticorps, des fragments de liaison à l'antigène de ceux-ci, et des conjugués anticorps-médicament de ceux-ci ; et des procédés de fabrication et d'utilisation de telles compositions pharmaceutiques pour le traitement du cancer chez un patient ayant besoin d'un traitement.