ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF

The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase / phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Metho...

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Hauptverfasser:	RAMACHANDRAN, SREEKANTH A, KHAN, FARHA, PATNI, SAGAR, JADHAVAR, PRADEEP S, CHAKRAVARTY, SARVAJIT, PENDHARKAR, DHANANJAY, SAEED, UZMA, ANSARI, AMANTULLAH, GUPTA, ASHU, PUJALA, BRAHMAM, SAPRA, SHREYA, SONI, SANJEEV, DANODIA, ABHINANDAN, SATHE, BALAJI DASHRATH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase / phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed. La présente invention concerne des composés utiles dans le traitement d'états associés à un dysfonctionnement de l'enzyme pyrophosphatase pyrophosphatase/phosphodiestérase 1 (ENPP1). Spécifiquement, la présente invention concerne un composé de formule (J) qui présente une activité inhibitrice vis-à-vis de l'ENPP1. L'invention concerne également un procédé de traitement d'états associés à une surexpression du gène ENPP1 avec un tel composé. L'invention concerne également leurs utilisations, une composition pharmaceutique et des kits. Formule (J)