STABLE LIQUID LIPID NANOPARTICLE FORMULATIONS

The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at -20°C and rethawing. La présente invention concern...

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Bibliographische Detailangaben
Hauptverfasser:	VARGAS MONTOYA, NATALIA, KARVE, SHRIRANG, PATEL, PRIYAL, DEROSA, FRANK, SARODE, ASHISH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at -20°C and rethawing. La présente invention concerne, entre autres, une formulation de nanoparticules lipidiques liquides (LNP) encapsulant un ARNm codant pour un peptide ou un polypeptide, qui est résistant à l'agrégation et à la dégradation de l'ARNm suivant de multiples cycles de congélation à -20 °C et de re-décongélation.