PURIFICATION PLATFORMS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS HAVING A REDUCED HYDROLYTIC ENZYME ACTIVITY RATE

PURIFICATION PLATFORMS FOR OBTAINING PHARMACEUTICAL COMPOSITIONS HAVING A REDUCED HYDROLYTIC ENZYME ACTIVITY RATE

The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step and/or a MM-HIC/ IEX chromatography step, and are useful for providing a method of reducing a hydrolytic enzyme activity rate of a composition obtained fro...

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Bibliographische Detailangaben
Hauptverfasser: LEE, MICHAEL, YIGZAW, YINGES, WONG, MARC, O'DWYER, WILLIAM, WOON, STEPHEN, SEAY, ALEX, KHOO, STEFANIE, LIM, AMY, DUENAS, EILEEN T
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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Beschreibung
Zusammenfassung:The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step and/or a MM-HIC/ IEX chromatography step, and are useful for providing a method of reducing a hydrolytic enzyme activity rate of a composition obtained from said purification platforms. Also disclosed herein are methods of using the purification platforms described herein and compositions obtained therefrom, such as pharmaceutical compositions. La présente invention concerne des plateformes de purification comprenant une étape de filtration en profondeur et/ou une étape de chromatographie d'interaction hydrophobe (HIC) et/ou une étape de chromatographie MM-HIC/IEX, qui sont utiles pour fournir un procédé de réduction d'un taux d'activité d'hydrolyse enzymatique d'une composition obtenue à partir desdites plateformes de purification. L'invention concerne également des procédés d'utilisation des plateformes de purification selon la présente invention et des compositions obtenues à partir de celles-ci, telles que des compositions pharmaceutiques.