PYRAZOLE DERIVATIVES AS RET KINASE INHIBITORS

PYRAZOLE DERIVATIVES AS RET KINASE INHIBITORS

Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I ar...

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Hauptverfasser: BOLDRON, CHRISTOPHER PIERRE ALBERT JEAN, MOURET, TIPHAINE, PANCALDI, THOMAS PIERRE DINO, ANDREWS, STEVEN W, MCKENNEY, MEGAN L, PILKINGTON-MIKSA, MICHAEL ALEXANDER, IRVIN, THOMAS C, ANDERSON, ERIN D, MCFADDIN, ELIZABETH A, MUNCHHOF, MICHAEL J, CONDROSKI, KEVIN R, PINTO, MARTA, MCLEAN, JOHNATHAN ALEXANDER, KUMAR, MANOJ, KOLAKOWSKI, GABRIELLE R. A/K/A JODY GABRIELLE RUSTMANN KOLAKOWSKI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed. L'invention concerne des composés de formule I : ou un sel pharmaceutiquement acceptable de ceux-ci, les variables étant telles que définies dans la description. Ces composés sont utiles dans le traitement de cancers associés à RET. L'invention concerne également des formulations contenant les composés de formule I et des procédés de préparation des composés de formule I.