CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF

CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF

CFTR modulator compounds and compositions including said compounds are provided. The present disclosure also provides PDE4 inhibiting compounds and compositions including said compounds. Also provided are methods of using said compounds and compositions for modulating CFTR, methods for treating an e...

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Hauptverfasser: KIM, JUNGHO, LIM, DAMI, JEONG, ILJI, AN, KYUNG MI, LEE, MYONGJAE, KIM, KYEONG-A, LEE, JUNG WOO, YOON, JONGMIN, LEE, SEOLHEE, RYU, JAEEUN, KWON, JINSUN, JUN, YEARIN, OH, CHANGMOK, YOON, HONGCHUL, LEE, JOOYUN, LEE, JIN HEE, SOHN, TE-IK, KIM, GUNHEE, PARK, JOONTAE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:CFTR modulator compounds and compositions including said compounds are provided. The present disclosure also provides PDE4 inhibiting compounds and compositions including said compounds. Also provided are methods of using said compounds and compositions for modulating CFTR, methods for treating an eye disease or disorder and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4, for treating an inflammatory disease or disorder and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds. La divulgation concerne des composés modulateurs de CFTR et des compositions comprenant lesdits composés. La présente divulgation concerne également des composés inhibiteurs de PDE4 et des compositions comprenant lesdits composés. La divulgation concerne également des procédés d'utilisation desdits composés et compositions pour la modulation de CFTR, des procédés de taitement d'une maladie ou d'un trouble oculaire et des procédés de traitement d'indications liées au CFTR. La présente divulgation concerne également des procédés d'utilisation desdits composés et compositions pour inhiber PDE4, traiter une maladie ou un trouble inflammatoire et traiter d'autres indications liées à PDE4. L'invention concerne également des procédés de préparation desdits composés et compositions, ainsi que des précurseurs synthétiques desdits composés.