CRYSTAL FORM OF MULTI-SUBSTITUTED BENZENE RING COMPOUND MALEATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

CRYSTAL FORM OF MULTI-SUBSTITUTED BENZENE RING COMPOUND MALEATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Provided are a crystal form of a multi-substituted benzene ring compound maleate, and a preparation method therefor and the use thereof. The crystal form of the multi-substituted benzene ring compound salt represented by formula II has good physicochemical stability, high solubility, less hygroscopi...

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Bibliographische Detailangaben
Hauptverfasser: HU, YONGHAN, WANG, WENGUI, WENG, QIUPING, LI, XIN, WANG, XUFAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided are a crystal form of a multi-substituted benzene ring compound maleate, and a preparation method therefor and the use thereof. The crystal form of the multi-substituted benzene ring compound salt represented by formula II has good physicochemical stability, high solubility, less hygroscopicity, good flowability and more preparation process options, and is more suitable for industrial production, which is of great value for drug optimization and development. L'invention concerne une forme cristalline d'un composé maléate à cycle benzénique multi-substitué, son procédé de préparation et son utilisation. La forme cristalline du sel de composé à cycle benzénique multi-substitué représenté par la formule II a une bonne stabilité physico-chimique, une faible hygroscopicité, une bonne aptitude à l'écoulement et plusieurs options de traitement de préparation, et est plus appropriée pour une production industrielle, ce qui est d'une grande valeur pour l'optimisation et le développement de médicament.