A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Comp...

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Hauptverfasser: REUTER, KARL, SINGH, AMARJIT, PEREGO, LUCA ALESSANDRO, WEI, CAROLYN S, WAGSCHAL, SIMON ALBERT, ZHDANKO, ALEXANDER, TRAN, NGOC DUC, WISNIEWSKI, STEVEN R, XIOURAS, CHRISTOS, LEMAIRE, SEBASTIEN FRANCOIS EMMANUEL, JAMISON, CHRISTOPHER ROBERT, SCHMALZBAUER, BJORN, SFOUGGATAKIS, CHRIS, MUKHERJEE, SUBHA, CUNIERE, NICOLAS, ZHENG, BIN, GALLAGHER, WILLIAM P, SKLIAR, DIMITRI, LUO, HELEN Y, JUSSEAU, XAVIER JEAN-MARIE, BEN HAIM, CYRIL, MATCHA, KIRAN, KOLOTUCHIN, SERGEI, ORTIZ, ADRIAN, KOSCHKER, PHILIPP, EASTGATE, MARTIN D, BROGGINI, DIEGO FERNANDO DOMENICO, MOWER, MATTHEW PENFIELD, CHERNICHENKO, KOSTIANTYN, RAHMANI, RAMDANE, CAO, DUY CHI TRUNG
Format: Patent
Sprache:eng ; fre
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I). La présente invention concerne de manière générale plusieurs procédés pour la préparation de (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phényl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluorométhyl)-6-méthyl-1,4,7,8,9,10-hexahydro-11,15-(methéno)pyrazolo[4,3-b][1,7]diazacyclotétradécin-5(6H)-one (composé (I)).