NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER

The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of D...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	JAMIESON, STEPHEN MICHAEL FRAZER, DICKSON, BENJAMIN D, HAY, MICHAEL PATRICK, WILSON, WILLIAM ROBERT, WONG, WAY WUA, LIEW, LYDIA PIENG PING, HONG, CHO RONG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to substituted imidazo[4,5-c]pyridine-2-one compounds of Formula (I) and prodrugs of said compounds. Compounds of Formula (I) selectively inhibit the activity of DNA-dependent protein kinase (DNA-PK) and are therefore useful in the treatment of diseases in which inhibition of DNA-PK is beneficial. L'invention concerne des composés imidazo[4,5-c]pyridine-2-one substitués de Formule I et des promédicaments desdits composés. Les composés de formule I inhibent sélectivement l'activité de la protéine kinase dépendante de l'ADN (DNA-PK) et sont par conséquent utiles dans le traitement de maladies dans lesquelles l'inhibition de la DNA-PK est bénéfique.(I)