COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins avß6 and avß3. Preferably the RGD-motif containing fusion p...

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Bibliographische Detailangaben
Hauptverfasser:	DUFFY, CIARA, BLANCAFORT, PILAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins avß6 and avß3. Preferably the RGD-motif containing fusion peptide can reduce viability of cancer cells, including in particular, TNBC and HER2-enriched breast cancer cells, and ovarian cancer cells. La présente invention se rapporte au domaine des compositions et des méthodes de traitement du cancer. En particulier, l'invention concerne de nouveaux peptides de fusion de mélittine comprenant un peptide contenant un motif RGD qui se lie aux intégrines avß6 et avß3. De Préférence, le peptide de fusion contenant un motif RGD peut réduire la viabilité de cellules cancéreuses, notamment en particulier des cellules du cancer du sein enrichies en TNBC et HER2, et des cellules cancéreuses ovariennes.