NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) INHIBITOR-CONJUGATES AND USES THEREOF

The present application relates to nicotinamide phosphoribosyltransferase (NAMPT) inhibitor-linker conjugates of Formula (I) comprising NAMPT inhibitors linked to linker groups, to processes and intermediates for their preparation, and to compositions comprising these compounds, as well as their use...

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Bibliographische Detailangaben
1. Verfasser:	MAMAI, AHMED
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present application relates to nicotinamide phosphoribosyltransferase (NAMPT) inhibitor-linker conjugates of Formula (I) comprising NAMPT inhibitors linked to linker groups, to processes and intermediates for their preparation, and to compositions comprising these compounds, as well as their use, for example, in the treatment or diagnosis of diseases and conditions, including, but not limited to, cancer. (I) La présente invention concerne des conjugués de lieur- inhibiteur de nicotinamide phosphoribosyltransférase (NAMPT) de formule (I) comprenant des inhibiteurs de NAMPT liés à des groupes de liaison, des procédés et des intermédiaires pour leur préparation, et des compositions comprenant ces composés, ainsi que leur utilisation, par exemple, dans le traitement ou le diagnostic de maladies et d'états pathologiques, comprenant, entre autres, le cancer. (I)