USE OF TERTIARY LYMPHOID STRUCTURES FOR THE PROGNOSIS OF DISEASE PROGRESSION OR TREATMENT IN CANCER

The present invention relates to an in vitro method for the prognosis of disease progression in a patient that suffers from or is at risk of developing cancer, said method comprising the step of determining, in a sample from said patient which is suspected to comprise neoplastic or cancerous tissue,...

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Bibliographische Detailangaben
Hauptverfasser:	ITALIANO, ANTOINE, LE LOARER, FRANCOIS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to an in vitro method for the prognosis of disease progression in a patient that suffers from or is at risk of developing cancer, said method comprising the step of determining, in a sample from said patient which is suspected to comprise neoplastic or cancerous tissue, whether or not the sample comprises a tertiary lymphoid structure (TLS), and prognosing disease progression, wherein the prognosis is an assessment regarding the likelihood of improved survival of the patient, and/or better clinical outcome of an immunotherapy. La présente invention concerne une méthode in vitro destinée au pronostic de progression de la maladie chez un patient souffrant d'un cancer ou susceptible d'en développer un, ladite méthode comprenant l'étape consistant à déterminer, dans un échantillon provenant dudit patient chez qui un tissu néoplasique ou cancéreux est suspecté, si l'échantillon comprend ou non une structure lymphoïde tertiaire (TLS) et à pronostiquer la progression de la maladie, le pronostic étant une évaluation concernant la probabilité de survie améliorée du patient et/ou un meilleur résultat clinique d'une immunothérapie.