COMPOUNDS FOR AND METHODS OF TREATING DISEASES

The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurologi...

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Bibliographische Detailangaben
Hauptverfasser:	BOND, SILAS, PARSONS, JACK GORDON, HUGGINS, PENELOPE JANE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides heterocyclic compounds of formula (I) that modulate biological metals and to pharmaceutical compositions containing such compounds. The invention particularly relates to compounds that modulate iron and to compounds for the treatment of diseases, particularly neurological diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Alzheimer-type dementia, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and multiple system atrophy (MSA). (I) La présente invention concerne des composés hétérocycliques représentés par la formule (I), qui modulent des métaux biologiques, et des compositions pharmaceutiques contenant de tels composés. L'invention concerne en particulier des composés qui modulent le fer et des composés pour le traitement de maladies, en particulier de maladies neurologiques telles que la maladie de Parkinson (MP), la maladie d'Alzheimer (MA), la démence de type Alzheimer, la maladie de Huntington (MH), la sclérose latérale amyotrophique (SLA), la démence frontotemporale (DFT) et l'atrophie multisystématisée (AMS). (I)