SEMI-BATCH PROCESSES FOR THE CRYSTALLIZATION OF A SOLID COMPRISING AN ACTIVE PHARMACEUTICAL INGREDIENT, ITS INTERMEDIATE, OR A SALT THEREOF

The present invention provides semi-batch processes for the crystallization of a compound (an API, intermediate, or salt thereof) wherein a continuous flow suspension comprising the compound undergoes dissolution by passage through a heated tubular heat exchanger to afford a solution that is induced...

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Bibliographische Detailangaben
Hauptverfasser:	SOUZA, FABIO E.S, KARADEOLIAN, AVEDIS, REY, ALLAN W, KONDAMREDDY, MURALI, STRADIOTTO, DAVID A, PATEL, DINESHKUMAR, ROELAND, GERRY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUSPOLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE APPARATUS THEREFOR CHEMISTRY CRYSTAL GROWTH HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE REFINING BY ZONE-MELTING OF MATERIAL SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE SINGLE-CRYSTAL-GROWTH UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL ORUNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL
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Beschreibung
Zusammenfassung:	The present invention provides semi-batch processes for the crystallization of a compound (an API, intermediate, or salt thereof) wherein a continuous flow suspension comprising the compound undergoes dissolution by passage through a heated tubular heat exchanger to afford a solution that is induced to crystallize in batch mode.