CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjug...

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Hauptverfasser: ZHAO, ROBERT, YE, HANGBO, DU, YONG, LIN, CHEN, CHEN, XIAOXIAO, YE, RIPING, BAI, LU, ZHENG, WEI, CAI, XIANG, WANG, XIAOXU, GUO, ZHIXIANG, ZHANG, XIUZHEN, ZHANG, LINGLI, JIA, JUNXIANG, JIANG, XINYAN, LI, YANHUA, CHEN, MIAOMIAO, XU, YIFANG, CHEN, DIANCHENG, KONG, XIANGFEI, GUO, HUIHUI, YANG, QINGLIANG, ZHAO, GENGXIANG, ZHENG, JUN, ZHENG, YUNXIA, HUANG, YUANYUAN, LI, WENJUN, HUANG, SHANGMA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and --- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders. L'invention concerne des conjugués d'analogues de camptothécine avec une molécule de liaison cellulaire de formule (I), où R1, R2, R3, R4, R5, X, L, n, m, T et --- sont tels que définis dans la description. L'invention concerne également des procédés de fabrication des conjugués d'analogues de camptothécine avec un agent de liaison cellulaire, ainsi que des procédés d'utilisation de ces conjugués dans le traitement ciblé du cancer, d'une infection et de troubles immunologiques.