NOVEL AMORPHOUS ACTIVE PHARMACEUTICAL INGREDIENTS

The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also dir...

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Bibliographische Detailangaben
Hauptverfasser:	FAGERBERG, JONAS, ASBERG, PETER, IVARSSON, CAROLINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to a solid and substantially amorphous active pharmaceutical ingredient, to an oral pharmaceutical formulation comprising said substantially amorphous active pharmaceutical ingredient, as well as to a method for the manufacture of the same. The invention is also directed to the use of a particulate anhydrous and substantially amorphous mesoporous magnesium carbonate (MMC) to stabilize an active pharmaceutical ingredient (API). La présente invention concerne un ingrédient pharmaceutique actif solide et sensiblement amorphe, une formulation pharmaceutique pour administration par voie orale comprenant ledit ingrédient pharmaceutique actif sensiblement amorphe, ainsi qu'un procédé de fabrication de celui-ci. L'invention concerne également l'utilisation d'un carbonate de magnésium mésoporeux (MMC) particulaire anhydre et sensiblement amorphe pour stabiliser un ingrédient pharmaceutique actif (API).