PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES USING MODIFIED OXIDATION PROTOCOL

The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme. applying a novel oxidation protocol and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	JAITZ, LEONHARD, GEISER, ACHIM, FETTES, ALEC
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PHYSICS SUGARS TESTING
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II according to the scheme. applying a novel oxidation protocol and to new oxidation solutions. L'invention concerne un procédé de production d'un oligonucléotide à squelette mixte P=O/P=S, comprenant une oxydation sélective d'un composé triester de phosphite intermédiaire de formule I en un composé phosphodiester de formule II selon le schéma appliquant un nouveau protocole d'oxydation, et de nouvelles solutions d'oxydation.