QUINOLINE COMPOUNDS AND COMPOSITIONS FOR INHIBITING EZH2

The invention disclosed herein relates to aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combin...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, JI YUE (JEFF), PAPILLON, JULIEN, DORE, MICHAEL, YU, ZHENGTIAN, MI, YUAN, LI, LING, GU, XIANG-JU JUSTIN, DAI, XUAN, LIU, KUN CHIN, MAK, SING YEUNG FRANKIE, ZHAO, KEHAO, OYANG, COUNDE, YAN, XIAOXIA, QI, WEI (VICKY)
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention disclosed herein relates to aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof. L'invention concerne des composés d'aza-quinoléine de formule (I), des compositions pharmaceutiques comprenant de tels composés; et l'utilisation de tels composés pour traiter une maladie ou affection médiée par l'activateur de l'homologue 2 de Zeste (EZH2), le complexe répressif Polycomb 2 (PRC2), ou une combinaison de ceux-ci.