COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE
The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of...
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| creator | LI, TENGFEI HINRICHS, JURGEN HANS-HERMANN FAIRHURST, ROBIN ALEC LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND WILCKEN, RAINER LEBLANC, CATHERINE TODOROV, MILEN VAUPEL, ANDREA MURA, CHRISTOPHE GERSPACHER, MARC WARIN, NICOLAS NIETO-OBERHUBER, CRISTINA MONTSERRAT LORTHIOIS, EDWIGE LILIANE JEANNE FRITSCH, CHRISTINE |
| description | The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.
La présente invention concerne des composés de formule (I) ou une forme de sel pharmaceutiquement acceptable de ceux-ci, les substituants étant tels que définis dans la description ; des intermédiaires utilisés dans la préparation des composés, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans le traitement de maladies. Les composés sont des inhibiteurs ou des modulateurs de HIF2alpha. |
| format | Patent |
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La présente invention concerne des composés de formule (I) ou une forme de sel pharmaceutiquement acceptable de ceux-ci, les substituants étant tels que définis dans la description ; des intermédiaires utilisés dans la préparation des composés, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans le traitement de maladies. Les composés sont des inhibiteurs ou des modulateurs de HIF2alpha.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211104&DB=EPODOC&CC=CA&NR=3180109A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211104&DB=EPODOC&CC=CA&NR=3180109A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI, TENGFEI</creatorcontrib><creatorcontrib>HINRICHS, JURGEN HANS-HERMANN</creatorcontrib><creatorcontrib>FAIRHURST, ROBIN ALEC</creatorcontrib><creatorcontrib>LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND</creatorcontrib><creatorcontrib>WILCKEN, RAINER</creatorcontrib><creatorcontrib>LEBLANC, CATHERINE</creatorcontrib><creatorcontrib>TODOROV, MILEN</creatorcontrib><creatorcontrib>VAUPEL, ANDREA</creatorcontrib><creatorcontrib>MURA, CHRISTOPHE</creatorcontrib><creatorcontrib>GERSPACHER, MARC</creatorcontrib><creatorcontrib>WARIN, NICOLAS</creatorcontrib><creatorcontrib>NIETO-OBERHUBER, CRISTINA MONTSERRAT</creatorcontrib><creatorcontrib>LORTHIOIS, EDWIGE LILIANE JEANNE</creatorcontrib><creatorcontrib>FRITSCH, CHRISTINE</creatorcontrib><title>COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE</title><description>The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.
La présente invention concerne des composés de formule (I) ou une forme de sel pharmaceutiquement acceptable de ceux-ci, les substituants étant tels que définis dans la description ; des intermédiaires utilisés dans la préparation des composés, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans le traitement de maladies. Les composés sont des inhibiteurs ou des modulateurs de HIF2alpha.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeod5gKWxm50OaaJM2CT0kwFV6FIXIkW6v0xiAdw9Xnw3l8WUfu284NrAqBr4EuBhb0LYH0P7IiPmd0JhAygFr6wXMFbILa7Es8dYQkIOc4C99AaIZ_vsjEEsy4W9_Exp81vVwVYI5q2aXrFNE_jLT3TO2qs1b5S1QFV_YfyAbTQMgk</recordid><startdate>20211104</startdate><enddate>20211104</enddate><creator>LI, TENGFEI</creator><creator>HINRICHS, JURGEN HANS-HERMANN</creator><creator>FAIRHURST, ROBIN ALEC</creator><creator>LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND</creator><creator>WILCKEN, RAINER</creator><creator>LEBLANC, CATHERINE</creator><creator>TODOROV, MILEN</creator><creator>VAUPEL, ANDREA</creator><creator>MURA, CHRISTOPHE</creator><creator>GERSPACHER, MARC</creator><creator>WARIN, NICOLAS</creator><creator>NIETO-OBERHUBER, CRISTINA MONTSERRAT</creator><creator>LORTHIOIS, EDWIGE LILIANE JEANNE</creator><creator>FRITSCH, CHRISTINE</creator><scope>EVB</scope></search><sort><creationdate>20211104</creationdate><title>COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE</title><author>LI, TENGFEI ; HINRICHS, JURGEN HANS-HERMANN ; FAIRHURST, ROBIN ALEC ; LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND ; WILCKEN, RAINER ; LEBLANC, CATHERINE ; TODOROV, MILEN ; VAUPEL, ANDREA ; MURA, CHRISTOPHE ; GERSPACHER, MARC ; WARIN, NICOLAS ; NIETO-OBERHUBER, CRISTINA MONTSERRAT ; LORTHIOIS, EDWIGE LILIANE JEANNE ; FRITSCH, CHRISTINE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3180109A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI, TENGFEI</creatorcontrib><creatorcontrib>HINRICHS, JURGEN HANS-HERMANN</creatorcontrib><creatorcontrib>FAIRHURST, ROBIN ALEC</creatorcontrib><creatorcontrib>LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND</creatorcontrib><creatorcontrib>WILCKEN, RAINER</creatorcontrib><creatorcontrib>LEBLANC, CATHERINE</creatorcontrib><creatorcontrib>TODOROV, MILEN</creatorcontrib><creatorcontrib>VAUPEL, ANDREA</creatorcontrib><creatorcontrib>MURA, CHRISTOPHE</creatorcontrib><creatorcontrib>GERSPACHER, MARC</creatorcontrib><creatorcontrib>WARIN, NICOLAS</creatorcontrib><creatorcontrib>NIETO-OBERHUBER, CRISTINA MONTSERRAT</creatorcontrib><creatorcontrib>LORTHIOIS, EDWIGE LILIANE JEANNE</creatorcontrib><creatorcontrib>FRITSCH, CHRISTINE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI, TENGFEI</au><au>HINRICHS, JURGEN HANS-HERMANN</au><au>FAIRHURST, ROBIN ALEC</au><au>LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND</au><au>WILCKEN, RAINER</au><au>LEBLANC, CATHERINE</au><au>TODOROV, MILEN</au><au>VAUPEL, ANDREA</au><au>MURA, CHRISTOPHE</au><au>GERSPACHER, MARC</au><au>WARIN, NICOLAS</au><au>NIETO-OBERHUBER, CRISTINA MONTSERRAT</au><au>LORTHIOIS, EDWIGE LILIANE JEANNE</au><au>FRITSCH, CHRISTINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE</title><date>2021-11-04</date><risdate>2021</risdate><abstract>The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha.
La présente invention concerne des composés de formule (I) ou une forme de sel pharmaceutiquement acceptable de ceux-ci, les substituants étant tels que définis dans la description ; des intermédiaires utilisés dans la préparation des composés, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans le traitement de maladies. Les composés sont des inhibiteurs ou des modulateurs de HIF2alpha.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE |
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