COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE

COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2.ALPHA. A ND THEIR METHODS OF USE

The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of...

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Bibliographische Detailangaben
Hauptverfasser: LI, TENGFEI, HINRICHS, JURGEN HANS-HERMANN, FAIRHURST, ROBIN ALEC, LANGLOIS, JEAN-BAPTISTE GEORGES ARMAND, WILCKEN, RAINER, LEBLANC, CATHERINE, TODOROV, MILEN, VAUPEL, ANDREA, MURA, CHRISTOPHE, GERSPACHER, MARC, WARIN, NICOLAS, NIETO-OBERHUBER, CRISTINA MONTSERRAT, LORTHIOIS, EDWIGE LILIANE JEANNE, FRITSCH, CHRISTINE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha. La présente invention concerne des composés de formule (I) ou une forme de sel pharmaceutiquement acceptable de ceux-ci, les substituants étant tels que définis dans la description ; des intermédiaires utilisés dans la préparation des composés, des compositions pharmaceutiques comprenant les composés et l'utilisation des composés dans le traitement de maladies. Les composés sont des inhibiteurs ou des modulateurs de HIF2alpha.