SUBSTITUTED PYRAZOLYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are compounds, compositions and methods useful for inhibiting lactate dehydrogenase (LDH) activity and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to LDH activity, or the accumulation of oxalate, including hyperoxaluria. L&#...

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Bibliographische Detailangaben
Hauptverfasser:	DING, JINYUE, POWELL, DAVID ANDREW, GOMEZ, ROBERT, BOILY, MARC-OLIVIER, SHENG, TAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds, compositions and methods useful for inhibiting lactate dehydrogenase (LDH) activity and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to LDH activity, or the accumulation of oxalate, including hyperoxaluria. L'invention concerne des composés, des compositions et des méthodes utiles pour l'inhibition de l'activité de la lactate déshydrogénase (LDH) et pour le traitement, la prévention et l'atténuation d'un ou plusieurs symptômes de maladies ou de troubles associés à l'activité de la LDH, ou à l'accumulation d'oxalate, y compris l'hyperoxalurie.