TGFBR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE, FUSION PROTEIN OF TGFBR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE AND ANTI-EGFR ANTIBODY, AND ANTI-TUMOR USE OF FUSION PROTEIN

TGFBR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE, FUSION PROTEIN OF TGFBR2 EXTRACELLULAR DOMAIN TRUNCATED MOLECULE AND ANTI-EGFR ANTIBODY, AND ANTI-TUMOR USE OF FUSION PROTEIN

Provided are multiple types of TGF?R2 in truncated forms and a fusion protein constructed by TGF?R2 and EGFR antibody HPA8; also provided are a nucleic acid (comprising heavy/light chain variable regions) encoding the antibody, and a vector, a pharmaceutical composition, and a kit comprising the nuc...

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Bibliographische Detailangaben
Hauptverfasser: GUO, ERHONG, SUN, CHUNYUN, XIE, LIANGZHI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided are multiple types of TGF?R2 in truncated forms and a fusion protein constructed by TGF?R2 and EGFR antibody HPA8; also provided are a nucleic acid (comprising heavy/light chain variable regions) encoding the antibody, and a vector, a pharmaceutical composition, and a kit comprising the nucleic acid; further provided is a fusion protein of the prepared truncated form of TGF?R2 receptor protein and a targeted EGFR and other multiple types of tumor target antibodies. L'invention concerne de multiples types de TGF?R2 dans des formes tronquées et une protéine de fusion construire par la TGF?R2 et l'anticorps EGFR HPA8; l'invention concerne également un acide nucléique (comprenant des régions variables de chaîne lourde/légère) codant l'anticorps, et un vecteur, une composition pharmaceutique et un kit comprenant l'acide nucléique; l'invention concerne en outre une protéine de fusion de la forme tronquée préparée de la protéine réceptrice TGF?R2 et d'un EGFR ciblé et d'autres multiples types d'anticorps cibles tumoraux.