METHOD FOR THE PRODUCTION AND PURIFICATION OF MULTIVALENT IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS

The present disclosure relates to an improved method for the manufacture of polypeptides comprising at least three or at least four immunoglobulin single variable domains (ISVDs). More specifically, an improved method is provided of producing, purifying and isolating polypeptides comprising at least...

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Bibliographische Detailangaben
Hauptverfasser:	MADURA, FLORIAN, BORSALI, CHAKIB, VAN HOREN, ELLEN, LETESTU, SONIA, BRIGE, ANN, MERCHIERS, TOM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates to an improved method for the manufacture of polypeptides comprising at least three or at least four immunoglobulin single variable domains (ISVDs). More specifically, an improved method is provided of producing, purifying and isolating polypeptides comprising at least three or at least four ISVDs in which an undesired product- related conformational variant is reduced or absent. La présente divulgation concerne un procédé amélioré pour la production de polypeptides comprenant au moins trois ou au moins quatre domaines variables uniques d'immunoglobuline (ISVD). Plus particulièrement, l'invention concerne un procédé amélioré pour la production, la purification et l'isolement de polypeptides comprenant au moins trois ou au moins quatre ISVD, un variant conformationnel lié au produit indésirable étant réduit ou absent.