ANTI-TMPRSS6 ANTIBODIES AND USES THEREOF

Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided. L'invention co...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, BUXIN, WANG, YU JEAN, DU, XIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided. L'invention concerne des anticorps, et des fragments de ceux-ci de liaison à l'antigène, qui se lient à la sérine protéase transmembranaire 6 de type II (TMPRSS6) sur la surface d'une cellule et augmentent l'expression de l'hepcidine, et des méthodes de traitement de troubles du métabolisme du fer à l'aide d'anticorps anti-TMPRSS6 et de fragments de ceux-ci.