MODIFIED FC REGIONS

MODIFIED FC REGIONS

The present invention relates to the field of modified constant domains of canine or feline antibodies having altered immune-effector functions and their use. More specifically, the application relates to modified Fc fragments having significantly reduced FcyRI and C1q binding. La présente invention...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STERNER, ANDREA, BRAND, VERENA, WALDHUBER, MARKUS, SCHNEIDER, CHRISTINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to the field of modified constant domains of canine or feline antibodies having altered immune-effector functions and their use. More specifically, the application relates to modified Fc fragments having significantly reduced FcyRI and C1q binding. La présente invention concerne les domaines à constantes modifiées d'anticorps canins ou félins ayant des fonctions immunitaires effectrices modifiées et leur utilisation. Plus spécifiquement, l'invention concerne des fragments Fc modifiés à liaison FcyRI et C1q significativement réduites.