PHARMACEUTICAL COMBINATION OF A THERAPEUTIC OLIGONUCLEOTIDE TARGETING HBV AND A TLR7 AGONIST FOR TREATMENT OF HBV

The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a...

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Bibliographische Detailangaben
Hauptverfasser:	ZHU, YONGHONG, JIN, YUYAN, GAO, LU, OTTOSEN, SOREN, MUELLER, HENRIK, TYAGI, GAURAV, BLAISING, JULIE ELISABETH FRANCOISE, BO, QINGYAN, ZHOU, XUE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a chronic hepatitis B patient. La présente invention concerne des compositions et des méthodes de traitement d'une infection par le virus de l'hépatite B. Plus précisément, la présente invention concerne une polythérapie comprenant l'administration d'un oligonucléotide thérapeutique ciblant le VHB et un agoniste de TLR7 destinée à être utilisée pour le traitement d'un patient atteint d'hépatite B chronique.