ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS

ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS

Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described. L'inventi...

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Bibliographische Detailangaben
Hauptverfasser: SPROTT, KEVIN TYLER, SAULNIER, MARK GEORGE, KARRA, SRINIVASA, RAY, SOUMYA, CHEN, JESSE JINGYANG, WILES, JASON ALLAN
Format: Patent
Sprache:eng ; fre
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CHEMISTRY
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ORGANIC CHEMISTRY
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Zusammenfassung:Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described. L'invention concerne des composés et des compositions qui ont un ligand se liant au récepteur de l'asialoglycoprotéine (ASGPR), lié à un ligand se liant à une protéine extracellulaire pour la dégradation sélective de la protéine extracellulaire cible in vivo afin de traiter des troubles médiés par la protéine extracellulaire.