ANTIBODIES BINDING TO HLA-A2/MAGE-A4

The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BUJOTZEK, ALEXANDER, KEISER, SIMON PATRICK, FAUTI, TANJA, WEINZIERL, TINA, KLOSTERMANN, STEFAN, HANISCH, LYDIA JASMIN, KLEIN, CHRISTIAN, MARRER-BERGER, ESTELLE, UMANA, PABLO, CARPY GUTIERREZ CIRLOS, ALEJANDRO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease. La présente invention concerne de manière générale des anticorps qui se lient à HLA-A2/MAGE-A4, comprenant des anticorps multispécifiques, par exemple pour activer des lymphocytes T. De plus, la présente invention concerne des polynucléotides codant pour de tels anticorps, et des vecteurs et des cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des anticorps, et des procédés d'utilisation de ceux-ci dans le traitement d'une maladie.