ANTI-SARS-COV-2 SPIKE RECEPTOR BINDING DOMAIN (RBD) SINGLE DOMAIN ANTIBODIES AND METHODS OF USE THEREOF

Provided herein is an antibody which specifically binds severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike receptor binding domain (RBD, comprising at least one heavy chain variable region comprising complementarity determining regions CDR-H1, CDR-H2, and CDR-H3, wherein the amino ac...

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Hauptverfasser:	DORMESHKIN, DMITRI, SHAPIRA, MICHAIL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein is an antibody which specifically binds severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike receptor binding domain (RBD, comprising at least one heavy chain variable region comprising complementarity determining regions CDR-H1, CDR-H2, and CDR-H3, wherein the amino acid sequences CDR-H3 comprises the sequence of CDRH-3 as found in SEQ ID NOs: 4, 8, 12, 16, 19, 23, 27 and/or 31 or an affinity maturated variant thereof. Methods of treating SARS-CoV-2 and/or COVID-19 using said antibody are also provided.