COMBINATIONS OF DGK INHIBITORS AND CHECKPOINT ANTAGONISTS

Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD1/PD-L1 axis and/or an a...

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Hauptverfasser:	RAHAMAN, HASIBUR, OLSON, RICHARD E, MANNOORI, RAJU, GENTLES, ROBERT G, ROY, SAUMYA, DARNE, CHETAN P, DASGUPTA, BIRESHWAR, CHUPAK, LOUIS S, HUANG, YAZHONG, WEE, SUSAN, WANG, XINYU, GRUNENFELDER, DENISE, TOKARSKI, JOHN S, MCDONALD, IVAR M, KAMBLE, MANJUNATHA NARAYANA RAO, MARTIN, SCOTT W, WICHROSKI, MICHAEL J, WARRIER, JAYAKUMAR SANKARA, DING, MIN, BENCI, JOSEPH L, JALAGAM, PRASADA RAO, REDDY, KOTHA RATHNAKAR, TONUKUNURU, GOPIKISHAN, VELAIAH, SIVASUDAR, VELAPARTHI, UPENDER, ZHENG, XIAOFAN, RAJA, THIRUVENKADAM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD1/PD-L1 axis and/or an antagonist of CTLA4. L'invention concerne des inhibiteurs de diacylglycérol kinases (DGK) et des procédés de traitement de maladies qui bénéficieraient de la stimulation du système immunitaire, tels que le cancer et les maladies infectieuses, comprenant l'administration d'un inhibiteur de DGK en combinaison avec un antagoniste de l'axe PD1/PD-L1 et/ou un antagoniste de CTLA4.