BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE

The disclosure provides BRD9 bifunctional compounds of Formula (A) or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders me...

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Bibliographische Detailangaben
Hauptverfasser:	HOLLINGWORTH, GREGORY JOHN, VULPETTI, ANNA, CHEN, XIN, HARRINGTON, EDMUND MARTIN, SENDZIK, MARTIN, ZOLLER, THOMAS, LORBER, JULIEN, GOUDE, MARIE-LINE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure provides BRD9 bifunctional compounds of Formula (A) or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodoma in-containing protein 9 (BRD9) L'invention concerne des composés bifonctionnels BRD9 de formule (A) ou un sel pharmaceutiquement acceptable, hydrate, solvate, promédicament, stéréoisomère, ou un tautomère de celui-ci, leur préparation, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de maladies et de troubles à médiation par une protéine contenant un bromodomaine, telle que la protéine 9 contenant un bromodomine (BRD9).