ANTIBODIES BINDING TO CD3 AND CD19

The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods f...

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Bibliographische Detailangaben
Hauptverfasser:	GONZALEZ NICOLINI, MARIA VALERIA, KNAUPP, ALEXANDER, TROCHANOWSKA, HALINA, WALDHAUER, INJA, HOSSE, RALF, FREIMOSER-GRUNDSCHOBER, ANNE, KLEIN, CHRISTIAN, MOESSNER, EKKEHARD, RICHTER, WOLFGANG, UMANA, PABLO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease. La présente invention concerne de manière générale des anticorps qui se lient à CD3 et CD19, par exemple pour activer des lymphocytes T. De plus, la présente invention concerne des polynucléotides codant pour de tels anticorps, et des vecteurs et des cellules hôtes comprenant de tels polynucléotides. L'invention concerne en outre des procédés de production des anticorps et des procédés d'utilisation de ceux-ci dans le traitement d'une maladie.