CD8 BINDING AGENTS AND USES THEREOF

Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding...

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Bibliographische Detailangaben
Hauptverfasser:	SRIRAMAN, SHRAVAN KUMAR, KIEFER, JAMES RICHARD, KOERBER, JAMES THOMAS, GILL, HERMAN SINGH, URRUTIA, ALEJANDRA BEATRICE URPI, DAVIES, CHRISTOPHER WILLIAMSON, WILLIAMS, SIMON-PETER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease. L'invention concerne des agents de liaison à CD8 comprenant un domaine VHH qui se lie de manière spécifique à CD8. L'invention concerne également des acides nucléiques codant pour de tels agents de liaison à CD8, des vecteurs comprenant de tels acides nucléiques, des cellules hôtes les comprenant, et des procédés de production de tels agents de liaison à CD8. L'invention concerne en outre des agents de liaison à CD8 comprenant un domaine VHH conjugué à une étiquette détectable. L'invention concerne des procédés d'utilisation de ces agents de liaison à CD8 pour détecter des lymphocytes T CD8+, surveiller la progression d'une maladie, et surveiller la progression du traitement chez un sujet atteint d'un cancer, d'une maladie ou d'une affection auto-immune, d'un rejet de greffe ou d'une maladie du greffon contre l'hôte.