METHODS OF TREATING BREAST CANCER WITH TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS

The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer...

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Bibliographische Detailangaben
Hauptverfasser:	TAYLOR, IAN CHARLES ANTHONY, GOUGH, SHERYL MAXINE, CHEN, XIN, MOORE, MARCIA DOUGAN, WANG, JING, CREW, ANDREW P, FLANAGAN, JOHN, HASKELL, ROYAL J, QIAN, YIMIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein. La présente invention concerne le traitement et/ou la prévention du cancer du sein, comprenant le cancer du sein localement avancé ou métastatique, ER+, HER2-, chez un sujet ayant besoin d'un traitement, comprenant l'administration d'un composé de formule (I), (I), ou d'un sel, énantiomère, stéréoisomère, solvate, polymorphe, dérivé isotopique ou promédicament pharmaceutiquement acceptable de celui-ci, R1, R2, R3, R4, m et n étant tels que définis dans la description.