MEDICINAL AND/OR PHARMACEUTICAL COMPOSITIONS FOR INTRAVESICAL INSTILLATION, PREPARATION AND USE THEREOF

The present invention relates to novel medicinal and/or pharmaceutical compositions indicated as composition A and composition B in liquid form for use as a medicinal composition or medicament for intravesical instillation, in the simultaneous local treatment of diseases of the urethra and/or the bladder, where compositions A and B are for use advantageously in the treatment of bladder pain syndrome (interstitial cystitis), in the urethra, and by replenishment of the GAG-layer on the inner surface of the bladder, further advantageously composition A is for use for local analgesic and anaesthetic treatment of the urethra and/or the bladder, and further advantageously the treatment of inflammation of the urethra and/or the bladder and preparation thereof. According to the use of the compositions of the subject matter of the invention, the treatment of the IC/BPS is implemented in two steps using first composition A and secondly composition B for intravesical instillation through the urethra. Osmolarity and pH of the compositions are also optimized. According to the subject matter of the invention composition A comprises the following components: Local anaesthetic, advantageously Lidocaine or adequate salt thereof, corticosteroid, advantageously dexamethasone-disodium-diphosphate or non-steroid anti-inflammatory agent, advantageously diclofenac salt, where furthermore advantageously the local anaesthetic and the non-steroid anti-inflammatory agent and advantageous forms thereof are embedded in liposome or further advantageously are composing complex with a complex composing agent; alkaline basic, advantageously sodium hydroxide; sterile distilled water; alkaline salt, advantageously sodium chloride. According to the subject matter of the invention, furthermore, composition B comprises the following components: Hyaluronic acid or adequate alkaline salt thereof, advantageously sodium-hyaluronate, alkaline salt of chondroitin sulfate, advantageously sodium- chondroitin-sulfate, heparin, advantageously sodium salt of heparin; alkaline basic, advantageously sodium hydroxide or sodium hydrogen carbonate, sterile distilled water, alkaline salt, advantageously sodium chloride and alkaline earth metal salt, advantageously calcium chloride. La présente invention concerne de nouvelles compositions médicinales et/ou pharmaceutiques indiquées en tant que composition A et composition B sous forme liquide pour une utilisation en tant que composition médicinale ou médicament