5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES

5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES

Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart...

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Bibliographische Detailangaben
Hauptverfasser: OMOTO, KIYOYUKI, REESE, MATTHEW RICHARD, FILIPSKI, KEVIN JAMES, ZHANG, YUAN, KORMOS, BETHANY LYN, MILLER, RUSSELL ALAN, BHATTACHARYA, SAMIT KUMAR, BUTLER, CHRISTOPHER RYAN, MARTINEZ-ALSINA, LUIS ANGEL, ROTH FLACH, RACHEL JANE, RAYMER, BRIAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure. L'invention concerne des composés de formule (I),R1, R2, et R3 étant tels que définis dans la description, leur utilisation en tant qu'inhibiteurs de kinase alpha-céto-déshydrogénase à chaîne ramifiée, des compositions pharmaceutiques contenant de tels inhibiteurs et l'utilisation de tels inhibiteurs pour traiter, par exemple, le diabète, la NASH et l'insuffisance cardiaque.