MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer. La présente invention concerne des agents ph...

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Bibliographische Detailangaben
Hauptverfasser:	ROMBOUTS, FREDERIK JAN RITA, SURKYN, MICHEL, JERHAOUI, SOUFYAN, JOUFFROY, MATTHIEU DOMINIQUE, VAN ROOSBROECK, YVES EMIEL MARIA, DIELS, GASTON STANISLAS MARCELLA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer. La présente invention concerne des agents pharmaceutiques de formule (I) utiles pour la thérapie et/ou la prophylaxie chez un sujet, une composition pharmaceutique comprenant de tels composés, et leur utilisation en tant qu'inhibiteurs de MCL-1, utiles pour le traitement de maladies telles que le cancer.