A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE

A formulation of conjugates of tubulysin analogs with a cell-binding molecule haying a stntcture represented by Formula (I), wherein T, L, m, n, --- 7 R1, R2, R3, R4, R5, R6, R7, R8, R9, RH), RI% R12, and x ¨ 13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease,...

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Hauptverfasser:	ZHAO, ROBERT, YE, HANGBO, DU, YONG, LIN, CHEN, CHEN, XIAOXIAO, ZHOU, XIAOMAI, JIANG, XINGYAN, BAI, LU, ZHANG, YU, ZHAO, LINYAO, GAI, SHUN, GUO, ZHIXIANG, ZHANG, XIUZHEN, ZHANG, LINGLI, JIA, JUNXIANG, ZHOU, LEI, LI, YANHUA, CHEN, MIAOMIAO, XU, YIFANG, ZHENG, XIUHONG, KONG, XIANGFEI, GUO, HUIHUI, CHEN, BINBIN, YANG, YANLEI, YANG, QINGLIANG, ZHENG, JUN, DAI, MENG, HUANG, YUANYUAN, FAN, ZHONGLIANG, LI, WENJUN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A formulation of conjugates of tubulysin analogs with a cell-binding molecule haying a stntcture represented by Formula (I), wherein T, L, m, n, --- 7 R1, R2, R3, R4, R5, R6, R7, R8, R9, RH), RI% R12, and x ¨ 13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease. Une formulation de conjugés d'analogues de tubulysine avec une molécule de liaison au récepteur de la surface cellulaire ayant une structure représentée par la formule (I), dans laquelle T, L, m, n, ---, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, et R13 sont définies, peut être utilisé pour le traitement ciblé de cancer, de maladie auto-immune et de maladie infectieuse.